教員紹介

kohta◆nue.ac.jp　　※「◆」を「@」に変えてお使いください。

論文

[1] Ohta E, Itoh M, Ueda M, Hida Y, Wang MX, Hayakawa-Ogura M, Li S, Nishida E, Ohta K, Tana, Islam S, Nakagawa K, Sunayama T, Chen H, Hirata S, Endo M, Ohno Y, Nakagawa T.
Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity
PLoS ONE 22;14(7):e0219782. 2019.

[2] Nakagawa T and Ohta K.
Quercetin controls integrated stress response to improve memory.
Int J Mol Sci. 5;20(11):2761. 2019.

[3]　Nakagawa T, Itoh M, Ohta K, Hayashi Y, Hayakawa M, Yamada Y, Akanabe H, Chikaishi T, Nakagawa K, Itoh Y, Muro T, Yanagida D, Nakabayashi R, Mori T, Saito K, Ohzawa K, Suzuki C, Li S, Ueda M, Wang MX, Nishida E, Islam S, Na T, Kobori M, Inuzuka T.
Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer’s disease patients.
NeuroReport 27:671-6, 2016.

[4]　Wang MX, Itoh M, Li S, Hida Y, Ohta K, Hayakawa M, Nishida E, Ueda M, Islam S, Tana, Nakagawa T.
CED-4 is an mRNA-binding protein that delivers ced-3 mRNA to ribosomes.
Biochem Biophys Res Commun. 470:48-53, 2016.

[5]　Hayakawa M, Itoh M, Ohta K, Li S, Ueda M, Wang MX, Nishida E, Islam S, Suzuki C, Ohzawa K, Kobori M, Inuzuka T, Nakagawa T.
Quercetin reduces eIF2alpha phosphorylation by GADD34 induction.
Neurobiology of Aging 36: 2509-2518, 2015.

[6] Ueda M, Li S, Itoh M, Hayakawa-Yano Y, Wang MX, Hayakawa M, Hasebe-Matsubara R, Ohta K, Ohta E, Mizuno A, Hida Y, Matsumoto M, Chen H, Nakagawa T.
Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax.
Biochem Biophys Res Commun. 443:1232-1238, 2014.

[7]　Li S, Hayakawa-Yano Y, Itoh M, Ueda M, Ohta K, Suzuki Y, Mizuno A, Ohta E, Hida Y, Wang MX, Nakagawa T.
Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system.
Brain Res. 1488: 1-13, 2012.

[8]　Ohta K, Mizuno A, Li S, Itoh M, Ueda M, Ohta E, Hida Y, Wang MX, Furoi M, Tsuzuki Y, Sobajima M, Bohmoto Y, Fukushima T, Kobori M, Inuzuka T, Nakagawa T.
Endoplasmic reticulum stress enhances γ-secretase activity. Biochem. Biophys. Res. Commun. 416:362-6, 2011.

[9]　Li S, Itoh M, Ohta K, Ueda M, Mizuno A, Ohta E, Hida Y, Wang MX, Takeuchi K, Nakagawa T.
The expression and localization of Prune2 mRNA in the central nervous system.
Neuroscience Letters 503:208-14, 2011.

[10]　Itoh M, Li S, Ohta K, Yamada A, Hayakawa-Yano Y, Ueda M, Hida Y, Suzuki Y, Ohta E, Mizuno A, Banno Y, Nakagawa T.
Cayman ataxia-related protein is a presynapse-specific caspase-3 substrate.

[11]　Ohta K, Mizuno A, Ueda M, Li S, Suzuki Y, Hida Y, Hayakawa-Yano Y, Itoh M, Ohta E, Kobori M, Nakagawa T.
Neurochem. Res. 36:1304-13, 2011.
Autophagy impairment stimulates PS1 expression and γ-secretase activity.
Autophagy 6:345-52, 2010.
＊ Faculty of 1000選出論文（FFa rating 8: Must read）

[12]　Suzuki Y, Ohta K*, Itoh M, Sakoh-Sumitomo Y, Mitsuda T, Ueda M, Hayakawa-Yano Y, Li S, Hida Y, Inuzuka T, Jung YK, Nakagawa T.
An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor.
FEBS letters 583:1403-8, 2009. *equally contribution

[13]　Mitsuda T, Hayakawa Y, Itoh M, Ohta K, Nakagawa T.
ATF4 regulates gamma-secretase activity during amino acid imbalance.
Biochem. Biophys. Res. Commun. 352:722-7, 2007.

著書

1. 「認知症と機能性食品」（ケルセチン、認知症と医農連携）2018. フジメディカル出版
2. 食べ物と健康「食品学総論」（2,4章）2017. 光生館
3. 食べ物と健康「食品学各論・食品加工学」（2,5章）2017. 光生館
4. 「食品と疾病－イソフラボン/ケルセチン」（ケルセチンとアルツハイマー病）
   Functional Food 16号: 135-138, 2011. フジメディカル出版
5. 「医農連携と機能性食品」（認知症）
   Functional Food 15号: 47-51, 2011. フジメディカル出版

所属学会

• Sigma Xi （The Scientific Research Honor Society）
• 北米神経科学会
• 日本分子生物学会
• 日本動物考古学会
• 日本食品保蔵科学会